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Heading into the College Football Playoff quarterfinals, three of the four matchups had a clear favorite. Ohio State, Georgia and Indiana were all at least five-point favorites — yet only the latter won, with the Buckeyes and Bulldogs suffering shocking upset losses.
Meanwhile, the Hoosiers took care of business against Alabama while the Oregon Ducks, a 1.5-point underdog at kickoff, manhandled the Texas Tech Red Raiders, showing tremendous tenacity on the defensive side of the ball.
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With three official upsets during the quarterfinals, the final four has been set.
The Ducks and Hoosiers will rehash their Week 7 meeting, in which Indiana stormed into Autzen Stadium and pulled out a 30-20 win, vaulting themselves to No. 2 in the nation. The Hurricanes and Rebels, the former sporting a physical defense and the latter a flashy offense, should make for a similarly intriguing matchup.
With the semifinals locked in, let's check out the national title odds, including a shocking difference in odds from last week to this week.
Indiana Hoosiers — (+128)
Indiana Hoosiers quarterback Fernando Mendoza (15) throws during the first half of the Big Ten Conference championship game against the Ohio State Buckeyes at Lucas Oil Stadium in Indianapolis on Dec. 6, 2025.
Previous Odds: +310
Record: 14-0
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What's Next: Peach Bowl vs. No. 5 Oregon
Oregon Ducks — (+320)
Oregon defensive back Brandon Finney Jr. celebrates an interception as the Oregon Ducks take on the Texas Tech Red Raiders in the Orange Bowl on Jan. 1, 2026, at Hard Rock Stadium in Miami, Florida.
Previous Odds: +800
Record: 13-1
What's Next: Peach Bowl vs. No. 1 Indiana
Miami Hurricanes — (+330)
Nov 15, 2025; Miami Gardens, Florida, USA; Miami Hurricanes head coach Mario Cristobal watches from the sideline against NC State Wolfpack during the third quarter at Hard Rock Stadium. Mandatory Credit: Sam Navarro-Imagn Images
Previous Odds: +2200
Record: 12-2
What's Next: Fiesta Bowl vs. No. 6 Ole Miss
Ole Miss Rebels — (+570)
Ole Miss head coach Lane Kiffin talks with quarterback Trinidad Chambliss (6) during a college football game between Mississippi State and Ole Miss at Davis Wade Stadium in Starkville, Miss., on Friday, Nov. 28, 2025. Ole Miss defeated Mississippi State 38-19 in the Egg Bowl.
Previous Odds: +2500
Record: 13-1
What's Next: Fiesta Bowl vs. No. 10 Miami
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This article originally appeared on Ducks Wire: National title odds entering the CFP semifinals
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