Rams-Cardinals opening odds Week 18

The Los Angeles Rams are 9.5-point favorites against the reeling Arizona Cardinals in Week 18, according to FanDuel Sportsbook. Arizona is far and away the worst team in the NFC West and is currently on an eight-game losing streak.

The Rams are coming off back-to-back losses to the Seahawks and Falcons. L.A. fell behind 24-3 in Atlanta before rallying to tie the game, until the Falcons decided to be clutch for once in their lives and come out on top after choking away a big lead. Well, thanks a lot, dirty birds!

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Arizona has seemingly punted on the year and is ready to move on to 2026. Who could blame them? This game’s spread will likely change depending on whether Sean McVay decides to rest starters while L.A. looks ahead to the postseason. If he does, that could shift things a bit, but maybe not substantially, given how poorly the Cardinals have played this season.

Expect the Cardinals to put up a decent fight early, before the Rams figure out a way to close things out as they seek some momentum entering the playoffs.

If you are interested in wagering on this game, then check out your options as FanDuel always offers a plethora of ways to wager, and ways to play with parlays, prop bets and whatever else you can think of.

PSA: Always bet responsibly, and try to have fun with it!