NFL rushing leaders since 2000

Indianapolis Colts running back Edgerrin James carries the ball against the Philadelphia Eagles at Veterans Stadium.

Cardinals safety Kwamie Lassiter, left, tackles Kansas City Chiefs player Priest Holmes at Sun Devil Stadium.

Miami Dolphins running back Ricky Williams breaks a long run for a touchdown against the New York Jets at Pro Player Stadium.

Baltimore Ravens running back Jamal Lewis in action against the Arizona Cardinals at Sun Devil Stadium.

Jets running back Curtis Martin picks up some first quarter yards against the Giants at the Meadowlands Aug. 26, 2005.

Seattle Seahawks running back Shaun Alexander tries to elude a tackle.

San Diego Chargers quarterback Philip Rivers hands the ball to running back LaDainian Tomlinson.

San Diego Chargers running back LaDainian Tomlinson.

Minnesota Vikings running back Adrian Peterson runs onto the field during the game against the Baltimore Ravens at M&T Bank Stadium.

Tennessee Titans running back Chris Johnson (28) runs for good yardage.

Houston Texans running back Arian Foster stiffarms New England Patriots safety Steve Gregory.

Jacksonville Jaguars running back Maurice Jones-Drew (32) runs for 56 yards. Spt 04jagscoltskj010

Green Bay Packers inside linebacker A.J. Hawk stops Minnesota Vikings running back Adrian Peterson.

Philadelphia Eagles running back LeSean McCoy rushes against the Denver Broncos in the fourth quarter at Sports Authority Field at Mile High.

Dallas Cowboys running back DeMarco Murray runs past Green Bay Packers free safety Ha Ha Clinton-Dix.

Minnesota Vikings running back Adrian Peterson acknowledges the fans at TCF Bank Stadium.

Dallas Cowboys running back Ezekiel Elliott.

Kansas City Chiefs running back Kareem Hunt before the game against the Denver Broncos at Sports Authority Field at Mile High.

Dallas Cowboys running back Ezekiel Elliott.

Tennessee Titans running back Derrick Henry races up the field during the third quarter against the Houston Texans at NRG Stadium.

Tennessee Titans running back Derrick Henry throws Buffalo Bills cornerback Josh Norman aside.

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Las Vegas Raiders running back Josh Jacobs.

Christian McCaffrey of the San Francisco 49ers carries the ball.

Oct 19, 2025; Minneapolis, Minnesota, USA; Philadelphia Eagles running back Saquon Barkley (26) controls the ball during the second half against the Minnesota Vikings at U.S. Bank Stadium. Mandatory Credit: Jeffrey Becker-Imagn Images

Buffalo Bills running back James Cook III rushes during the first quarter.